Barcode solution profiles keep clearing out targets under resources

I'm having an issue where over a period of time (week or months) the resources I add to a synchronization profile disappear.

I have the following empty.

USER, DEPT, COST CENTERS, PURCHASE ORDER, INVOICES, STOCKROOMS

I have LOCATION populated with 869 locations.

I have 4 targets I added by

"Apply To"

Exclude resource not IN ...

And each is just one filter.  One for MOnitors, PCs, network printers, and desk phones. Eventually, I'll sync and have no resources to associate to locations in the assign location section.  I check the sync profile and all 4 targets are gone.  Any idea what might be causing this?