Fresh install of Backup Exec 2012

Hello,

I have tried to dodge the bullet this time and avoided upgrading to BE 2012 until worst bugs are fixed. Now I think the time is right for upgrade, or is it?

I am planning to uninstall BE 2010 R3 and install 2012 on same server. What do I need to remember? Surely I have to backup catalogs, but what else? We are using deduplication storage, is that going to cause problems?